Plumbagin
CAS No. : 481-42-5
(Synonyms: 2-Methyljuglone)
| Size | Price | Stock |
|---|---|---|
| 50mg | $95 | In-stock |
| 100mg | $150 | In-stock |
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| Cat. No. : | HY-N1497 |
| M.Wt: | 188.18 |
| Formula: | C11H8O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 150 mg/mL |
Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities[1].
In Vitro: Plumbagin (0, 5, 10, and 15 μM) induces apoptosis of prostate cancer cell lines, such as DU145, CWR22rv1 and LNCaP, in a dose-dependent manner[1].
Plumbagin (5, 20 μM) obviously inhibits the invasion of PC3, DU145, and CWR22rv1 cells[1].
In Vivo: Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits the growth of tumor in male athymic nude mice[1].
Plumbagin (2 mg/kg, i.p., five days a week for 11 weeks) inhibits expression of PKCε, suppresses JAK-2 and Stat3 phosphorylation, and activates Stat3, PCNA, VEGF and MMP-9 in mice[1].
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