Juglone
CAS No. : 481-39-0
(Synonyms: 5-Hydroxy-1,4-naphthalenedione)
| Size | Price | Stock |
|---|---|---|
| 250mg | $19 | In-stock |
| 1g | $22 | In-stock |
| 5g | $52 | In-stock |
| 25g | $209 | In-stock |
| 50 g | Get quote | |
| 100 g | Get quote | |
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| Cat. No. : | HY-N6949 |
| M.Wt: | 174.16 |
| Formula: | C10H6O3 |
| Purity: | >98 % |
| Solubility: | Ethanol : 10 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity
[1][2][3].
In Vitro:Juglone (0-500 μg/mL, 15 h) shows significant antibacterial activity against Staphylococcus aureus, with MIC values ranging from 64-512 μg/mL[1].
Juglone(5-20 μM, 24 h) induces apoptosis of SGC-7901 cells through the mitochondrial pathway mediated by ROS production and the decrease of Bcl-2/Bax ratio[2].
In Vivo:Juglone (0.25 or 1 mg/kg, oral, 70 days) prevents metabolic endotoxemia-nduced hepatitis and neuroinflammation by inhibiting TLR4/NF-kB signaling pathway in high-fat diet rats[3].
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