Phloracetophenone

Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity^[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2^[2]. IC50 & Target:Cholesterol 7α-hydroxylase^[1], Mrp2^[2] In Vitro: Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level^[1].
Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver^[2]. In Vivo: Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis^[2].