Orsellinic acid
CAS No. : 480-64-8
| Size | Price | Stock |
|---|---|---|
| 100mg | $35 | In-stock |
| 250mg | $59 | In-stock |
| 1g | $150 | In-stock |
| 5g | $523 | In-stock |
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| Cat. No. : | HY-N3126 |
| M.Wt: | 168.15 |
| Formula: | C8H8O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). Orsellinic acid blocks PAF-mediated Apoptosis, inhibits caspase-3/7 activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer)[1][2][3].
In Vitro:Orsellinic acid (10 μg/mL; 72 h) shows no cytotoxicity against four human tumor cell lines (NCI-H460, MCF-7, SF-268, MIA Pa Ca-2) and normal human fibroblast cells WI-38[2].
Orsellinic acid (1 μg/mL for cell survival test) specifically blocks platelet-activating factor (PAF)-mediated neuronal apoptosis in PAFR⁻/⁻ mouse cerebellar granule neurons (CGNs) and PC12-AC cells, inhibits caspase-3/7 activation and PARP cleavage[3].
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