Retrorsine
CAS No. : 480-54-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $155 | In-stock |
| 5mg | $325 | In-stock |
| 10mg | $518 | In-stock |
| 25mg | $1035 | In-stock |
| 50mg | $1650 | In-stock |
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| Cat. No. : | HY-N6638 |
| M.Wt: | 351.39 |
| Formula: | C18H25NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury[1][2].
In Vitro: Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability and GSH levels, and increases formation of pyrrole-protein adducts[3].
In Vivo: Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle[4].
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