Dihydrokaempferol


CAS No. : 480-20-6

480-20-6
Price and Availability of CAS No. : 480-20-6
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1mg $45 In-stock
5mg $110 In-stock
10mg $180 In-stock
25mg $370 In-stock
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Cat. No. : HY-N2897
M.Wt: 288.25
Formula: C15H12O6
Purity: >98 %
Solubility: DMSO : 250 mg/mL (ultrasonic);H2O : < 0.1 mg/mL
Introduction of 480-20-6 :

Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1]. IC50 & Target:Apoptosis; Bcl-2; Bcl-xL[1] In Vitro: Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1].
Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1].
Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1].

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