Lucanthone
CAS No. : 479-50-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $255 | In-stock |
| 25mg | $510 | In-stock |
| 50mg | $815 | In-stock |
| 100mg | $1300 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B2098 |
| M.Wt: | 340.48 |
| Formula: | C20H24N2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). IC50 & Target: APE-1[1] In Vitro: Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50 of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results[2].
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- Lucanthone
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