ISO-1
CAS No. : 478336-92-4
(Synonyms: MIF Antagonist)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $244 | In-stock |
| 50mg | $390 | In-stock |
| 100mg | $620 | In-stock |
| 500mg | $1050 | In-stock |
| 1g | $1480 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-16692 |
| M.Wt: | 235.24 |
| Formula: | C12H13NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);Ethanol : 100 mg/mL (ultrasonic) |
ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM. IC50 & Target:IC50: 7 μM (MIF)[1] In Vitro: ISO-1 (0.1-20 μM; 16 hours) has a slight inhibitory effect on Cox-2 secretion without the addition of recombinant MIF[1]. In Vivo: ISO-1 (injected intraperitoneally; 3.5-35 mg/kg; twice daily; 2 weeks) improves the survival rate from lethal endotoxemia and shows the anti-inflammatory effect[2]. ISO-1 (intraperitoneal injection; 35 mg/kg; twice daily; 3 days) causes a significant reduction in average implant size and decreases Flk1 expression in implants[3].
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