DX600
CAS No. : 478188-26-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $500 | In-stock |
| 10mg | $900 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-P2222 |
| M.Wt: | 3074.33 |
| Formula: | C141H185N35O40S2 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic) |
DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity[1][2][3].
In Vitro:DX600 (1 μM) inhibits rhACE2 activity by 47%, with a pIC50 of 8.0[4].
DX600 (10 μM) inhibits ACE2 activity by 42% in human MNCs (mononuclear cells)[4].
DX600 (100 nM, 4 h) decreases NR 8383 cell growth and increase in TNF-a and IL-6 content in the supernatant (in the presence of LPS and osthole)[5].
In Vivo:DX600 (5 μg/kg/day, i.p., daily for 4 weeks) exacerbates diabetes-induced cardiovascular dysfunction in Streptozotocin (HY-13753)-treated diabetes rats[2].
DX600 (0.1 µmol/L/kg, i.v ) increases thrombus weight by 30% in thrombosis model in rats[5].
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