PHA-543613
CAS No. : 478149-53-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $135 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $820 | In-stock |
| 100mg | $1300 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-105670 |
| M.Wt: | 271.32 |
| Formula: | C15H17N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors[1]. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research[2]. IC50 & Target:Ki: 8.8 nM (α7 nAChR)[1] In Vivo:PHA-543613 (0.3 mg/kg) successfully reverses Scopolamine-induced short-term memory deficits in rats[2]. PHA-543613 (4 and 12 mg/kg; i.p. once) reduces behavioral deficits and brain edema is dependent on the PI3K-Akt signaling pathway[3].
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