Lucidin
CAS No. : 478-08-0
(Synonyms: NSC 30546)
| Size | Price | Stock |
|---|---|---|
| 5mg | $210 | In-stock |
| 10mg | $340 | In-stock |
| 25mg | $630 | In-stock |
| 50mg | $980 | In-stock |
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| Cat. No. : | HY-15733 |
| M.Wt: | 270.24 |
| Formula: | C15H10O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 6.67 mg/mL (ultrasonic) |
Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells.
In Vitro:Lucidin (0-30 μg/mL, 1 h) induces unprogrammed DNA synthesis in rat hepatocytes, induces single-strand DNA breaks and DNA-protein crosslinking in V79 cells, causes DNA damage and mutations[1].
Lucidin (0-30 μg/mL) induces malignant transformation of C3H/M2 mouse fibroblasts and forms transformation foci, exhibits potential carcinogenicity[1].
Lucidin (23 μM, 48 h) inhibits HPV E6, prevents the degradation of p53 protein, increases the protein expression of Bax, and activates caspase 3/7. Lucidin inhibits the cell viability of HeLa and Caski (IC50s are 23 μM and 45 μM), induces apoptosis in HeLa cell[3].
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