Buloxibutid (Standard)
CAS No. : 477775-14-7
(Synonyms: AT2 receptor agonist C21 (Standard))
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| Cat. No. : | HY-100113R |
| M.Wt: | 475.62 |
| Formula: | C23H29N3O4S2 |
| Purity: | >98 % |
| Solubility: |
Buloxibutid (AT2 receptor agonist C21) (Standard) is the analytical standard of Buloxibutid (HY-100113). This product is intended for research and analytical applications. Buloxibutid is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis. IC50 & Target:Ki: 0.4 nM (AT2) and >10 µM (AT1)[1]
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- Buloxibutid (Standard)
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- HY-100113R
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