Dehydrocostus Lactone

Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells^[1][2][3][4]. In Vitro:Dehydrocostus lactone (0-2 mg/L; 48 h) can reduce the viability, induce apoptosis, inhibit the expression of anti-apoptotic proteins, and increase the expression of pro-apoptotic proteins in DU145 cells^[1].
Dehydrocostus lactone (0-30 μmol/L; 0.5-8.5 h) can inhibit the phosphorylation of p38 MAPK, MK2, and Akt, the activation of NF-κB, reduce the expression of iNOS and the production of NO, and decrease the mRNA levels of pro-inflammatory cytokines such as TNF-α, IL-6, IL-1β, and IL-12 in RAW264.7 cells treated with LPS (HY-D1056)^[2]. In Vivo:Dehydrocostus Lactone (5-20 mg/kg; intraperitoneal injection; single administration) has a protective effect in a mouse model of LPS (HY-D1056)-induced acute lung injury^[2].