Demecolcine
CAS No. : 477-30-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $305 | In-stock |
| 50mg | $456 | In-stock |
| 100mg | $675 | In-stock |
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| Cat. No. : | HY-N0282 |
| M.Wt: | 371.43 |
| Formula: | C21H25NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
Demecolcine is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research[1][2].
In Vitro: Demecolcine (0.1-0.25 μg/ml, 1 h) reduces the the hypoploidy frequencies in metaphase II complements of mouse, rat and frog spermatocytes[3].
In Vivo: Demecolcine (0.3 mg/kg for intraperitoneal injection) increases the incidence of metaphase II hypoploidy in demecolcine treated mice[3].
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