MCI-225 (hydrate hydrochloride)

MCI-225 (DDP-225) hydrate hydrochloride is a selective and orally active noradrenaline (NA) reuptake inhibitor with 5-HT3 receptor antagonism. MCI-225 hydrate hydrochloride has antidepressant-like and anxiolytic-like properties. MCI-225 hydrate hydrochloride can be used for the study of anxiety disorder^[1][2]. In Vivo:In social interaction (SI) test in rats, MCI-225 (10 and 30 mg/kg, po) hydrate hydrochloride significantly increases SI to an unfamiliar partner under high light conditions without changes in ambulation. MCI-225 (10 mg/kg, po) hydrate hydrochloride shows comparable anxiolytic-like effect between single and 5-day repeated administration^[1].
In the Morris-type water maze task in rats, MCI-225 (1-10 mg/kg, PO) hydrate hydrochloride reduces the spatial learning impairment induced by Scopolamine (HY-N0296) (0.5 mg/kg, IP)^[2].
In a passive avoidance (PA) task in rats, administration of MCI-225 hydrate hydrochloride prior to training (1-30 mg/kg, PO) hydrate hydrochloride lessenes the carbon dioxide (CO2)-induced amnesia in a dose-dependent manner^[2].
MCI-225 (1-100 mg/kg) hydrate hydrochloride does not affect gross behavior in rats^[2].