Boldine
CAS No. : 476-70-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $35 | In-stock |
| 25mg | $50 | In-stock |
| 50mg | $65 | In-stock |
| 100mg | $78 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N6973 |
| M.Wt: | 327.37 |
| Formula: | C19H21NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research[1][2][3].
IC50 & Target:OPG/RANKL/RANK[1]
In Vitro:Boldine (10-500 μM, 24 h) inhibits the growth of bladder cancer cells in T24 patients[2].
Boldine (200-500 μM, 24 h) induces cycle arrest and apoptosis of bladder cancer cells in T24 by regulating ERK, AKT and GSK-3β[2].
In Vivo:Boldine (50 mg/kg, p.o, for 7 days) attenuates Dextran Sulfate Sodium (DSS) -induced colitis in mice via p65-NF-κB and STAT3 signaling pathways[3].
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