Chelidonine
CAS No. : 476-32-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $55 | In-stock |
| 5mg | $116 | In-stock |
| 10mg | $198 | In-stock |
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| Cat. No. : | HY-N2369 |
| M.Wt: | 353.37 |
| Formula: | C20H19NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity[1][2][3].
In Vitro:Chelidonine (5, 10 and 20 μM; 3-4 days) causes lesions and ventral curling in Dugesia japonica; and significantly decreases Djmcm2 expression at 20 μM but no reduction is observed at 5 and 10 μM; as well as prevents cell cycle progression of stem cells[2].
Chelidonine (0-3 μg/mL; 48 h) has cytotoxic activity against melanoma cell lines[3].
Chelidonine (1, 2 and 3 μg/mL; 24 h) decreases mitochondrial membrane potential (MMP) in 50% of A-375 cells at 1 and 1.5 μg/mL, and 62% at 3 μg/mL[3].
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