Isotretinoin
CAS No. : 4759-48-2
(Synonyms: 13-cis-Retinoic acid)
| Size | Price | Stock |
|---|---|---|
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| 500mg | $126 | In-stock |
| 1g | $195 | In-stock |
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| Cat. No. : | HY-15127 |
| M.Wt: | 300.44 |
| Formula: | C20H28O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Isotretinoin (13-cis-Retinoic acid) is an orally active vitamin A derivative and is often be used for the research of severe acne. Isotretinoin also shows anticancer activity[1][2].
In Vitro: Isotretinoin (13-cis-Retinoic acid) may act as a pro-drug that is converted intracellularly to metabolites that are agonists for RAR and RXR nuclear receptors[1].
Isotretinoin is highly sensitive to air, heat, and light[3].
Isotretinoin (0-40 μM; 24-96 h) significantly inhibits HepG2 cell viability[4].
Isotretinoin (10 μM; 48 h) down-regulates c-MYC mRNA expression and this is partially due to P1 or P2 promoter activity[4].
In Vivo: Isotretinoin (13-cis-Retinoic acid) (1.3-481 μg/L; inhalation exposure; 45 min daily for 2 weeks) is an effective lung cancer chemopreventive agent in A/J Mice[2].
Isotretinoin accelerates alveolar repair after exodontia in rats[3].
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