CORM-3
CAS No. : 475473-26-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $105 | In-stock |
| 50mg | $150 | In-stock |
| 100mg | $220 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100581 |
| M.Wt: | 294.61 |
| Formula: | C5H4ClNO5Ru |
| Purity: | >98 % |
| Solubility: | DMSO : 75 mg/mL (ultrasonic); |
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3]. In Vitro: CORM-3 suppresses caspase-1 activation and the secretion of interleukin (IL)-1β and IL-18 in macrophages in response to lipopolysaccharide (LPS) and ATP. CORM-3 inhibits the oligomerization of the adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which is required for NLRP3-dependent caspase-1 activation[2]. In Vivo: CORM-3 (4 mg/kg, ip) reduces NLRP3 inflammasome activation and inhibits hyperglycemia-induced inflammation in mice[2].
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