2-MeS-ADP (trisodium)
CAS No. : 475193-31-8
(Synonyms: 2-Methylthioadenosine diphosphate (trisodium); 2-Methylthio-ADP (trisodium))
| Size | Price | Stock |
|---|---|---|
| 10 mM * 927 μL in Water | $600 | In-stock |
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| Cat. No. : | HY-108648 |
| M.Wt: | 539.24 |
| Formula: | C11H14N5Na3O10P2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3]. In Vitro: 2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) is a powerful aggregating agent for human platelets. 2-Methylthioadenosine diphosphate trisodium is also a powerful inhibitor of the accumulation of cyclic AMP in intact platelets exposed to PGE1 and a phosphodiesterase inhibitor[1].
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