Monomethyl auristatin E (GMP)
CAS No. : 474645-27-7
(Synonyms: MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP))
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| Cat. No. : | HY-15162G |
| M.Wt: | 717.98 |
| Formula: | C39H67N5O7 |
| Purity: | >98 % |
| Solubility: | Ethanol : 50 mg/mL (ultrasonic;warming) |
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor[1].
In Vitro: Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30+ cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells[1].
Monomethyl auristatin E (MMAE) sensitizes colorectal and pancreatic cancer cells to IR in a schedule and dose dependent manner correlating with mitotic arrest. Radiosensitization is evidenced by decreased clonogenic survival and increased DNA double strand breaks in irradiated cells[2].
In Vivo: Monomethyl auristatin E (MMAE) in combination with IR results in tumor growth delay, tumor-targeted ACPP-cRGD-MMAE with IR produces a more robust and significantly prolongs tumor regression in xenograft models[2].
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