Atopaxar (hydrochloride)
CAS No. : 474544-83-7
(Synonyms: E5555 (hydrochloride); ER-172594-00 (hydrochloride))
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| Cat. No. : | HY-18200A |
| M.Wt: | 564.09 |
| Formula: | C29H39ClFN3O5 |
| Purity: | >98 % |
| Solubility: |
Atopaxar hydrochloride (E5555 hydrochloride) is the hydrochloride salt form of Atopaxar (HY-18200). Atopaxar hydrochloride is an orally active, selective and reversible antagonist for thrombin receptor protease-activated receptor-1 (PAR-1). Atopaxar hydrochloride is the inhibitor for Janus kinase 1 (JAK1) and JAK2, which inhibits the JAK-STAT with EC50 of 5.90 μM in A549. Atopaxar hydrochloride inhibits the cell viability of A549 (IC50=7.02 μM), arrests the cell cycle at G1 phase and induces apoptosis. Atopaxar hydrochloride exhibits antiplatelet and antitumor activities. Atopaxar hydrochloride can be used for the research of atherothrombotic disease[1][2][3].
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