Brassicasterol
CAS No. : 474-67-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $122 | In-stock |
| 5mg | $242 | In-stock |
| 10mg | $338 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-113289 |
| M.Wt: | 398.66 |
| Formula: | C28H46O |
| Purity: | >98 % |
| Solubility: | Ethanol : 4.76 mg/mL (ultrasonic) |
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC50=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease[1][2][3][4][5][6].
IC50 & Target:1.2 μM (HSV-1)[2]
24-reductase[5]
In Vitro:Brassicasterol (10 μM; 24 h) downregulates dihydrotestosterone (DHT)-induced expression of androgen receptor (AR) and prostate-specific antigen (PSA) in LNCaP cells [4].
Brassicasterol (50 μM; 48 h) Arrests the cell cycle of LNCaP in the sub-G1 phase and induces cell apoptosis [4].
Brassicasterol (10 μM; 48 h) also inhibits LNCaP cell migration [4].
Brassicasterol (100 μg /mL; 48 h) In a 3D organoid model, it can inhibit AKT, and its inhibitory effect on AR-independent cancers and AR-dependent cell[4].
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