Size | Price | Stock |
---|---|---|
5mg | $950 | In-stock |
10mg | $1500 | Get quote |
50 mg | Get quote | |
100 mg | Get quote | |
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Cat. No. : | HY-10011 |
M.Wt: | 425.48 |
Formula: | C23H27N3O5 |
Purity: | >98 % |
Solubility: | DMSO : ≥ 30 mg/mL (70.51 mM) |
SCH 563705 is a potent and orally available CXCR2 and CXCR1 antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively.
IC50 & Target: IC50: 1.3 nM (CXCR2), 7.3 nM (CXCR1)[1], 5.2 nM (Mouse CXCR2)[2]
Ki: 1 nM (CXCR2), 3 nM (CXCR1)[1]
In Vitro: SCH 563705 (Compound 16) is a potent and orally available CXCR2 and CXCR1 antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively. SCH 563705 shows potent inhibition against both Gro-a and IL-8 induced human neutrophil migration (chemotaxis IC50 = 0.5 nM, against 30 nM of Gro-a; chemotaxis IC50 = 37 nM, against 3 nM of IL-8)[1]. SCH 563705 potently inhibits mouse CXCR2 (IC50 = 5.2 nM)[2].
In Vivo: SCH 563705 has good oral pharmacokinetic profiles in rats, mice, monkeys and dogs[1]. SCH 563705 (50 mg/kg p.o) reduces blood Ly6G+ Ly6C+ neutrophil frequency and unchanged levels of Ly6GLy6Chi monocytes. SCH563705 (3-30 mg/kg p.o) treatment causes a dosedependent elevation in plasma levels of CXCL1[2].
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