WR99210
CAS No. : 47326-86-3
(Synonyms: BRL 6231 (free base))
| Size | Price | Stock |
|---|---|---|
| 5mg | $174 | In-stock |
| 10mg | $270 | In-stock |
| 25mg | $577 | In-stock |
| 50mg | $895 | In-stock |
| 100mg | $1388 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-116387 |
| M.Wt: | 394.68 |
| Formula: | C14H18Cl3N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine (HY-18062)-resistant P. falciparum strains) as well as T. gondii[1][2][3].
IC50 & Target:IC50: <0.075 nM (DHFR)[3].
In Vitro: WR99210 (0-100 nM; 92 h) is highly effective against T. gondii tachyzoites in tissue culture[1].
WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts[1].
In Vivo: WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model[1].
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