β-Eudesmol

β-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. β-Eudesmol is a neostigmine antagonist. β-Eudesmol can antagonize neostigmine-induced neuromuscular failure. β-Eudesmoll can be used in the study of sepsis diseases. β-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea^[1][2][3][4]. In Vitro: β-Eudesmol (30-100 μM; 6 days) can inhibit the cell proliferation induced by vascular endothelial growth factor (VEGF) (30 ng/ml) and basic fibroblast growth factor (bFGF) (30 ng/ml) in HUVEC cells, thereby inhibiting angiogenesis^[1].
β-Eudesmol (10-100 μM; 72 h) inhibits cell proliferation in a time- and dose-dependent manner in tumor in tumer cells HeLa, SGC-7901 and BEL-7402^[1].
β-Eudesmol (10-120 μM; 4 h) can reduce cell activity in HL-60 cells^[4].
β-Eudesmol (40-80 μM; 4 h) can activate caspase-3 by inducing the release of cytochrome c, thereby inducing cell apoptosis in HL-60 cells^[4].
In Vivo: β-Eudesmol (2.5-5 mg/kg; Intraperitoneal injection; Once daily for 7 days) significantly inhibits tumor cell and new blood vessel generation in MK mice^[1].
β-Eudesmol (50-100 mg/kg; Intraperitoneal injection; Single dose) can inhibit the NF-κb signaling pathway and has anti-inflammatory and antioxidant effects in C57BL/6 mice^[2].