SB-366791
CAS No. : 472981-92-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $92 | In-stock |
| 25mg | $198 | In-stock |
| 50mg | $317 | In-stock |
| 100mg | $528 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12245 |
| M.Wt: | 287.74 |
| Formula: | C16H14ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC50=5.7 nM). SB-366791 can be used for the research of inflammation[1][2]. IC50 & Target: IC50: 5.7 nM (hTRPV1)[2] In Vivo: SB-366791 (30 μM) inhibits the frequency of miniature excitatory postsynaptic currents (EPSCs). SB-366791 (30 μM) reduces the frequency of spontaneous EPSCs in the spinal cord slices from FCA-treated rats. SB-366791(30 μM) inhibits the amplitude of C-fibre evoked EPSCs. SB-366791 has also been used in vivo to assess the potential analgesic action of the inhibition of TRPV1, and significantly inhibits capsaicin-induced hypothermia, eye wiping movements and vasodilatation in the knee joint. SB-366791 inhibits glutamatergic transmission via an apparently pre-synaptic mechanism(s)[1].
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