Steviol


CAS No. : 471-80-7

471-80-7
Price and Availability of CAS No. : 471-80-7
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1mg $56 In-stock
5mg $119 In-stock
10mg $202 In-stock
25mg $365 In-stock
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100mg $810 In-stock
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Cat. No. : HY-N2057
M.Wt: 318.45
Formula: C20H30O3
Purity: >98 %
Solubility:
Introduction of 471-80-7 :

Steviol is the main metabolite of steviol glycosides and an inhibitor of AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2 and CFTR. Steviol can be used in the research of polycystic kidney disease[1][2]. In Vitro:Steviol (100 μM; 2-24 h) can reduce AQP2 protein expression in MDCK cell monolayers[1].
Steviol (100 μM; 17-21 days) can significantly reduce cyst diameter in the cyst model constructed with Pkd1⁻/⁻ mouse renal cystic epithelial cells[1]. In Vivo:Steviol (0.5-3.0 mg/kg/h; intravenous infusion; 30 minutes, twice) exerts diuretic, natriuretic, kaliuretic effects and inhibits renal tubular reabsorption of glucose in normal male Wistar rats (except at the dose of 0.5 mg/kg/h)[2].

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