Oxamic acid
CAS No. : 471-47-6
(Synonyms: Oxamidic acid)
| Size | Price | Stock |
|---|---|---|
| 5g | $30 | In-stock |
| 25g | $84 | In-stock |
| 100g | $278 | In-stock |
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| Cat. No. : | HY-W013032 |
| M.Wt: | 89.05 |
| Formula: | C2H3NO3 |
| Purity: | >98 % |
| Solubility: | H2O : 125 mg/mL (ultrasonic) |
Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].
In Vitro: Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1].
Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2].
Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2].
Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2].
Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2].
In Vivo: Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2].
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