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BMS-536924


CAS No. : 468740-43-4

468740-43-4
Price and Availability of CAS No. : 468740-43-4
Size Price Stock
1mg $43 In-stock
5mg $92 In-stock
10mg $158 In-stock
50mg $686 In-stock
100mg $800 In-stock
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Cat. No. : HY-10262
M.Wt: 479.96
Formula: C25H26ClN5O3
Purity: >98 %
Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 468740-43-4 :

BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity[1][2]. IC50 & Target: IC50: 100 nM (IGF-1R) and 73 nM (IR)[1][2] In Vitro: BMS-536924 inhibits FAK and Lck with IC50s of 150 nM and 341 nM, respectively[1].
BMS-536924 (1 μM; every four days for 12 days) blocks pBabe-MCF10A and CD8-IGF-IR-MCF10A acinar proliferation[2].
BMS-536924 (0.01-1 μM; 24 hours) inhibits growth of CD8-IGF-IR-MCF10A cells and has an IC50 of 0.48 μM[2].
BMS-536924 (1 μM; for 4 days) induces apoptosis in CD8-IGF-IR-MCF10A acini[2].
BMS-536924 (0.1-1 μM; for 24 hours) decreases in S-phase cells and causes a G0/G1 block[2].
BMS-536924 (1 μM; 10 min, 1, 8, 24, 48 hours) inhibits IGF-IR signaling in pBabe-MCF10A cells and inhibits phosphorylation of CD8-IGF-IR. BMS-536924 time-dependently inhibits AKT phosphorylation[2].
In Vivo: BMS-536924 (100 mg/kg; gavage; daily; for 35 days) causes regression of xenografts in vivo and an average reduction of 76% tumor volume after 2 weeks[2].

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