AFP464 (free base)
CAS No. : 468719-52-0
(Synonyms: NSC710464 (free base))
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| Cat. No. : | HY-16031 |
| M.Wt: | 448.44 |
| Formula: | C22H23F3N4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AFP464 (NSC710464) free base is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 free base downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 free base is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 free base is applicable to research related to breast cancer[1][2]. IC50 & Target:IC50：0.25 μM (HIF-1α)[1]
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