Idalopirdine
CAS No. : 467459-31-0
(Synonyms: Lu AE58054)
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| Cat. No. : | HY-14338 |
| M.Wt: | 398.37 |
| Formula: | C20H19F5N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Idalopirdine (Lu AE58054 ) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders[1][2].
In Vivo:Idalopirdine (intraperitoneal injection, 5?mg/kg, daily, 28 days) can reduce food intake and body weight in over-eating rat models[1].
Idalopirdine (1 or 2?mg/kg, i.v) can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats[2].
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