Idalopirdine (hydrochloride)
CAS No. : 467458-02-2
(Synonyms: Lu AE58054 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $255 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $530 | In-stock |
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| Cat. No. : | HY-14338A |
| M.Wt: | 434.83 |
| Formula: | C20H20ClF5N2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 25 mg/mL;H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders[1][2].
In Vivo: Idalopirdine (intraperitoneal injection, 5?mg/kg, daily, 28 days) hydrochloride can reduce food intake and body weight in over-eating rat models[1].
Idalopirdine (1 or 2?mg/kg, i.v) hydrochloride can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats[2].
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