Hecogenin
CAS No. : 467-55-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $60 | In-stock |
| 20mg | $90 | In-stock |
| 50mg | $130 | In-stock |
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| Cat. No. : | HY-N1422 |
| M.Wt: | 430.62 |
| Formula: | C27H42O4 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);DMF : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1]. IC50 & Target:Human UDP-glucuronosyltransferases[1] In Vivo: Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1].
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