Quinovic acid

Quinovic acid is triterpene. Quinovic acid can ameliorate the Amyloid-β burden, p53 expression and cholesterol accumulation by deterring the oxidative stress through upregulating the Nrf2/HO-1 pathway. Quinovic acid can induce cancer cells apoptosis by upregulating death receptor 5 (DR5). Quinovic acid can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as lung cancer and Alzheimer’s disease (AD)^[1][2]. In Vitro:Quinovic acid (5-115 μM, 24 h) shows low cytotoxicity and alleviates oligomeric Aβ (AβO)-induced cell death in SH-SY5Y cells^[1].
Quinovic acid (85 μM, 24 h) downregulates AβO-induced expressions of p53 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) in SH-SY5Y cells^[1].
Quinovic acid (QA) (5-40 μM, 24-72 h) inhibits the proliferation and viability of A549, H1299, MCF-7 and MDA-MB-231 cells^[2].
Quinovic acid (QA) (25-35 μM, 24 h) induces apoptosis in MDA-MB-231 and A549 cells^[2].
Quinovic acid (25 μM, 4-24 h) upregulates the mRNA and protein levels of death receptor 5 (DR5) in A549, MCF-7, and MDA-MB-231 cells^[2].
In Vivo:Quinovic acid (50 mg/kg, i.p., every other day for 3 weeks) significantly ameliorates Aβ(1-42)-induced pathological damage in C57BL/6J mice^[1].