Polyporenic acid C
CAS No. : 465-18-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $410 | In-stock |
| 25mg | $738 | In-stock |
| 50mg | $1180 | In-stock |
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| Cat. No. : | HY-N2993 |
| M.Wt: | 482.69 |
| Formula: | C31H46O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer[1].
IC50 & Target:IC50: apoptosis[1]
In Vitro:Polyporenic acid C (0-200 μM; 24-72 h) inhibits the proliferation of human non-small cell lung cancer A549 cells in a dose- and time-dependent manner[1].
Polyporenic acid C (60-100 μM; 24-48 h) increases the apoptosis rate of human non-small cell lung cancer A549 cells in a dose- and time-dependent manner[1].
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