Arenobufagin
CAS No. : 464-74-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
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| Cat. No. : | HY-N0876 |
| M.Wt: | 416.51 |
| Formula: | C24H32O6 |
| Purity: | >98 % |
| Solubility: |
Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway[1][2].
In Vitro:Arenobufagin (10 nM-10 μM, 48-72 h) potently inhibits the growth of both HepG2 and HepG2/ADM cells in a dose- and time-dependent manner, with the IC50 of 20.24 and 7.46 nM after 72 h[1].
Arenobufagin (20-500 nM, 24 h) increases the percentage of apoptotic (annexin positive) cells in HCC cells[1].
Arenobufagin (20-500 nM, 48 h) induces a specific cleavage of poly (ADP-ribose) polymerase (PARP) and a decrease in pro-caspase-9 and -3[1].
Arenobufagin (20 nM, 0-24 h) induces autophagic cell death and a significant increase in LC3-II in HepG2/ADM cells[1].
Arenobufagin (0-500 nM, 0-24 h) inhibits the activation of PI3K/Akt pathways in HCC cells[1].
Arenobufagin (0-125 nM, 12-48 h) inhibits cell viability in a dose- and time-dependent manner in HUVECs[2].
Arenobufagin (5-125 nM, 12-48 h) significantly suppresses VEGF-induced HUVECs viability in a dose- and time-dependent manner[2].
Arenobufagin (0-50 nM, 6 h) inhibits VEGF-induced endothelial cell migration and invasion[2].
In Vivo:Arenobufagin (3-6 mg/kg, i.p., 28 d) inhibits growth of HepG2/ADM cells xenografts in nude mice[1].
Arenobufagin (0-10 mg/kg, s.c., 21 d) inhibits VEGF-induced blood vessel formation in C57BL/6J mice[2].
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