(-)-Borneol
CAS No. : 464-45-9
(Synonyms: L-Borneol)
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| Cat. No. : | HY-N1368B |
| M.Wt: | 154.25 |
| Formula: | C10H18O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM. IC50 & Target:EC50: 237 μM (GABA receptor)[1] In Vitro: (-)-Borneol is an enantiomer of (+)-Borneol. (+)-Borneol is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. At high concentrations (>1.5 mM), (-)-Borneol directly activates GABAA receptors producing 84% of the maximal GABA response indicative of a weak partial agonist action. (-)-Borneol produces dose-dependent positive modulation of the Cl- conductance generated by extremely low dose GABA at α1β2γ2L GABAA receptors[1].
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