5-Chlorosalicylanilide

5-Chlorosalicylanilide is a bactericidal and antifungal compound. 5-Chlorosalicylanilide exhibits antibacterial activity against bacteria and fungistatic activity against dermatophytes. 5-Chlorosalicylanilide inhibits the photosynthetic electron flow required for nitrite reduction while stimulating nitrate reduction, leading to nitrite accumulation and NO_x release in soybean leaves. 5-Chlorosalicylanilide is used in the research of tinea capitis and dermatophytosis^{[1][2][3][4][5]}. In Vitro:5-Chlorosalicylanilide (0.001-2.5% by weight) is effective as a biocide in compositions comprising a surfactant system and a solvent^[1].
5-Chlorosalicylanilide (0.01-5% by weight) is effective as an antimicrobial agent in detergents and cleansing agents^[1].
5-Chlorosalicylanilide (0.01-5% by weight) is effective as an antimicrobial and deodorant agent in cosmetic preparations^[1].
5-Chlorosalicylanilide (M/20,000; 3 weeks) inhibitory activity against T. rubrum and T. mentagrophytes is not reversed by divalent metallic ions, suggesting that its mechanism of action does not involve chelation with free metallic ions in the growth medium^[5].
5-Chlorosalicylanilide (0.01-5% by weight) effectively preserves textile materials against fungi and bacteria^[1].
5-Chlorosalicylanilide (5 × 10^-3 M; 30 min) causes substantial NO_x evolution (8.7 μmol NO₂^- g^-1 fresh wt hr^-1) from soybean leaves under dark, aerobic conditions, demonstrating its ability to stimulate nitrate reduction^[2].
5-Chlorosalicylanilide (10^-3 M; 30 min) uniquely causes NO_x evolution in soybean leaves when used alone in both darkness and light, providing evidence that it not only stimulates nitrate reduction but also interferes with photosynthetic electron flow (approximately 44% inhibition in light without prometryn)^[2].
5-Chlorosalicylanilide (0.01 M; 0.005 M CuCl₂) does not chelate CuCl₂, as evidenced by potentiometric titration curves that are characteristic of non-chelating compounds^[5].
5-Chlorosalicylanilide (0.0001 M metallic ion; 0.001 M 5-Chlorosalicylanilide) does not form visible chelation complexes with metallic ions, supporting a non-chelating mechanism^[5].