Prifinium (bromide)
CAS No. : 4630-95-9
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| Cat. No. : | HY-122086 |
| M.Wt: | 386.37 |
| Formula: | C22H28BrN |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Prifinium bromide is an anticholinergic drug with anticholinergic and antispasmodic activities, and it exhibits oral activity. Prifinium bromide competitively antagonizes cholinergic receptors and relieves symptoms of spasm or hypermotility in the digestive and urinary tracts, with its anticholinergic activity representing the core mechanism underlying the inhibition of bladder smooth muscle contraction. Prifinium bromide can be used in research related to spasms and diverticular disease[1][2][3].
In Vitro:Prifinium bromide inhibits carbamoylcholine chloride (HY-B1208)-induced contraction of isolated guinea pig detrusor muscle, but exerts almost no effect on contractions induced by electrical stimulation, KCl or BaCl2[1].
Prifinium bromide exhibits anticholinergic activity in isolated guinea pig ileum, with a relative potency of 0.45 compared with Atropine (HY-B1205)[2].
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