Valencene

Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model^[1][2][3]. In Vitro: Valencene (10-100 μM, 1 h pre-treatment) significantly inhibits TNF-α/IFN-γ-stimulated chemokines secretion in HaCaT cells^[1].
Valencene (10-100 μM, 24 h) significantly increases involucrin mRNA/protein expression^[1]. In Vivo: Valencene (200 μL of 0-100 μM, topical, three times a week for 10 weeks) significantly decreases the SCORAD index in DNCB-sensitized NC/Nga mice^[1].