ONO-8130
CAS No. : 459841-96-4
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|---|---|---|
| 1mg | $380 | Get quote |
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| 10 mg | Get quote | |
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| Cat. No. : | HY-110198 |
| M.Wt: | 500.63 |
| Formula: | C25H28N2O5S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research[1].
In Vivo: ONO-8130 (0.3-30 mg/kg; Oral preadministration, once) strongly prevents both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent manner[1].
ONO-8130 (30 mg/kg; Orally, once) reverses the established cystitis-related bladder pain[1].
ONO-8130 (30 mg/kg; Orally, once) strongly inhibits phosphorylation of ERK in MDH, DCM, and SPN of the L6 spinal cord caused by intravesical administration of PGE2[1].
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