PEAQX
CAS No. : 459836-30-7
(Synonyms: NVP-AAM077)
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| Cat. No. : | HY-12294 |
| M.Wt: | 454.21 |
| Formula: | C17H17BrN3O5P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2].
IC50 & Target:IC50: 270 nM, 29.6 μM (hNMDAR 1A/2A, hNMDAR 1A/2B)[1].
In Vitro:PEAQX (3 μM) can induce cell apoptosis and promote caspase-3 activation in cortical striatal slice cultures[2].
In Vivo:PEAQX (10-40 mg/kg; s.c.) can increase caspase-3 activity and enhance motor activity in the frontal cortex and striatum of rats in a dose-dependent manner[2].
PEAQX (10 mg/kg; once daily; i.p.) can block the CaMKIV-TORC1-CREB pathway signal induced by sigma-1 receptor (σ 1r) agonists in mice with cerebral ischemia and improve learning and memory impairments[3].
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