SW033291
CAS No. : 459147-39-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $150 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $650 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16968 |
| M.Wt: | 412.59 |
| Formula: | C21H20N2OS3 |
| Purity: | >98 % |
| Solubility: | Ethanol : 25 mg/mL (ultrasonic);DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 70°C) |
SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM. SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration[1]. IC50 & Target: Ki: 0.1 nM (15-PGDH)[1] In Vitro: Treating cells with SW033291 decreases cellular 15-PGDH enzyme activity by 85%. SW033291 inhibition of 15-PGDH was non-competitive versus PGE2 over concentrations up to 40 μM PGE2. Treatment of A549 cells with SW033291 increases PGE2 levels by 3.5-fold at 500 nM, with an EC50 50 at approximately 75 nM[1]. In Vivo: SW033291 (10 mg/kg; intraperitoneal injection; twice daily; for 3 days; C57BL/6J mice) treatment for three consecutive days shows significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells[1].
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