Coniferaldehyde
CAS No. : 458-36-6
(Synonyms: 4-Hydroxy-3-methoxycinnamaldehyde)
| Size | Price | Stock |
|---|---|---|
| 100mg | $19 | In-stock |
| 250mg | $47 | In-stock |
| 1g | $150 | In-stock |
| 5g | $543 | In-stock |
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| Cat. No. : | HY-N2535 |
| M.Wt: | 178.19 |
| Formula: | C10H10O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities[1].
In Vitro:Coniferaldehyde (0.1-5 μM; Pretreatment with 1 h; and then treated with 24 h) exerts cytoprotective function against LPS-induced cell death and dramatically inhibits LPS-induced NO production as assessed by the Griess reaction in a dose dependent manner[1].
Coniferaldehyde (0.5-5 μM; 4-24 h) dramatically increases the Nrf-2 nuclear translocation and HO-1 expression. Furthermore, Coniferaldehyde specifically enhances the phosphorylation of PKCα/PKCβ II[1].
In Vivo:Coniferaldehyde (0.05 mmol kg/day; i.p; for 6 weeks) activates the Nrf2 signaling pathway in primary chondrocytes and articular cartilage from the knee joints. And Coniferaldehyde alleviates cartilage destruction in OA mice[2].
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