AA92593
CAS No. : 457961-34-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125145 |
| M.Wt: | 269.36 |
| Formula: | C13H19NO3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AA92593 is a selective and competitive OPN4 (melanopsin) antagonist[1][2].
In Vitro: AA92593 is a competitive melanopsin antagonist, its presence in the retinal-binding pocket of melanopsin leads to the displacement of retinal, which could trigger a downstream signaling that would ultimately result in Per1 increased expression[1].
AA92593 is shown to be specific because it competes with retinaldehyde for the melanopsin retinal binding site which is very distinct from other opsins[1].
Inhibition of melanopsin activity with AA92593 increases a-MSH expression and induces melanin dispersion in the melanophores, which darkens the embryo[3].
AA92593 exhibits an IC50 of 665 nM in CHOOpn4 cells[4].
In Vivo: AA92593 is able to decrease IOP in rabbits living under normal light condition[2].
AA92593 produces an increment in melatonin levels resulting in a drop of IOP[2].
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