Aegeline
CAS No. : 456-12-2
| Size | Price | Stock |
|---|---|---|
| 10g | $59 | In-stock |
| 25g | $105 | In-stock |
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| Cat. No. : | HY-W042156 |
| M.Wt: | 297.35 |
| Formula: | C18H19NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].
In Vitro: Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or
Bax-expressing cells[1].
Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin[2].
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