Corosolic acid

Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis^[1][2][3]. In Vitro: Corosolic acid shows cytotoxicity for Hep G2, A549, SNU-C4, HeLa, K-562 cells, with ED₅₀s of 0.4-5.0 μg/mL^[1].
Corosolic acid (0-50 μg/mL) inhibits PKC activity in a dose-dependent way^[1].
Corosolic acid (0-50 μM, 6-24 h) induces apoptosis and increases cells in the sub-G1 population in CT-26 cells^[3].
Corosolic acid (20 μM, 0-24 h) inhibits HER2/HER3 heterodimerization and phosphorylation of HER2 and HER3 in HCT116 and SW480 cells^[5].
In Vivo: Corosolic acid (5, 25 mg/kg/day, peritumor injection, 12 days) inhibits tumor growth and shows anti-angiogenic effect in CT-26 allograft colon carcinoma mice model^[3].
Corosolic acid (10 and 20 mg/kg, i.p., every 2 days) inhibits tumor growth in a murine PC-3 xenograft model by activating ER stress^[4].
Corosolic acid (10 mg/kg/d, supplemented in diet, 8 weeks) inhibits adipose tissue inflammation, and improves insulin resistance via AMPK activation in high-fat fed mice^[6].