DL-Homocysteine
CAS No. : 454-29-5
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|---|---|---|
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| 1g | $88 | In-stock |
| 5g | $383 | In-stock |
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| Cat. No. : | HY-W040821 |
| M.Wt: | 135.19 |
| Formula: | C4H9NO2S |
| Purity: | >98 % |
| Solubility: | H2O : 4.69 mg/mL (ultrasonic;warming;adjust pH to 2 with 1M HCl;heat to 60°C);H2O : 41.67 mg/mL (ultrasonic) |
DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity[2]. In Vitro:DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC50 value of 8.046 (5.804-11.154) mM[1]. In Vivo:DL-Homocysteine (1.3 mmol/kg, i.p.) increases KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 and 11.4 ± 1.72 in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 in rat hippocampus[1].
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