TIE-2/VEGFR-2 kinase-IN-1


CAS No. : 453590-24-4

453590-24-4
Price and Availability of CAS No. : 453590-24-4
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5mg $135 In-stock
10mg $220 In-stock
25mg $450 In-stock
50mg $750 In-stock
100mg $1200 In-stock
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Cat. No. : HY-112294
M.Wt: 241.25
Formula: C13H11N3O2
Purity: >98 %
Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 80°C)
Introduction of 453590-24-4 :

TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis[1]. In Vitro: Angiopoieten 1 is a ligand for the endotheiium-specific receptor tyrosine kinase, TIE-2 is a novel angiogenic factor[1].
Inhibition of TIE-2 is expected to serve to disrupt remodeling and maturation of new vasculature initiated by angiogenesis thereby disrupting the angiogenic process. Inhibition at the kinase domain binding site of VEGFR-2 would block phosphorylation of tyrosine residues and serve to disrupt initiation of angiogenesis.

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